After more than a decade of rising mortality, the USA is experiencing an unexpected and encouraging decline in drug overdose deaths. According to provisional estimates from the US Centers for Disease Control and Prevention, approximately 70 000 people died from drug overdoses in 2025—nearly 14% fewer than in 2024, marking the third consecutive annual decline, from a high of almost 108 000 in 2022.1,2 The reduction in overdose deaths has been widespread, as nearly every state in the country reported fewer overdose deaths in 2025 compared with the previous year.
Kaynak: The Lancet
