Objectives: The aim of this study is to investigate, at the molecular level, the effect of cardiopulmonary bypass (CPB) on Sirtuin-1 levels, an epigenetic-metabolic regulatory protein, and the relationship between this change and Caspase-3, one of the key executor molecules of cellular apoptosis.Methods: Patients undergoing open heart surgery under CPB were included in the study.
Sirtuin-1 and Caspase-3 levels were measured in venous blood samples taken from patients during the preoperative, intraoperative, and postoperative periods. The Wilcoxon Signed Ranks test was used to analyze differences between time points.Results: Sirtuin-1 levels decreased significantly during the intraoperative period compared to preoperative values (Z= -6.212, P