Objective: Remnant liver tissue is essential for the surgery of primary liver tumors, metastasectomy, or donor hepatectomy. We aimed to determine whether an effective supportive treatment can improve the safety of donors with insufficient remnants and expand the donor pool in countries where LDLT is performed intensively.
Therefore, our study investigated the effects of various substance extracts on the regenerative capacity of residual liver tissue following hepatectomy.Methods: Rats of equal age and approximately equal weight were grouped into 6 groups: Sham, Genabilic acid, Silymarin+curcumin, Ganoderma lucidum, Mixture containing group B vitamins, amino acids, l-carnitine, and sugars, and Phenoxy-2-methyl-2-propionic acid.
Subjects' mTOR, insulin, nesfatin, and leptin levels were checked. PCNA was performed for regeneration control, and immunohistochemistry for Ki-67, mTOR, VEGF, FGF, HGF, and Calpain-10 was performed on the liver.Results: In comparisons between the Sham group and the other groups, there were significant differences for insulin in group 4 (p=0.041) and for nesfatin in group 3 (p